## Abstract It has been reported that genomic DNA methylation decreases gradually during cell culture and an organism's aging. However, less is known about the methylation changes of ageβrelated specific genes in aging. p21^Waf1/Cip1^ and p16^INK4a^ are cyclinβdependent kinase (Cdk) inhibitors that
Oncogenic ras induces premature senescence in endothelial cells: role of p21Cip1/Waf1
β Scribed by Ioakim Spyridopoulos; Jeffrey M. Isner; Douglas W. Losordo
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 250 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0300-8428
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p21 WAF1/CIP1 is a downstream mediator of p53 and mediates growth arrest by inhibiting the action of G 1 cyclin-dependent kinases. Since cellular differentiation is frequently characterized by G 1 arrest, we examined whether p21 WAF1/CIP1 overexpression would induce growth suppression and differenti