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Relationship of a T-Lymphocyte marker to phase of cell cycle and morphology of leukemic cells

✍ Scribed by Zalmen A. Arlin; Jen Wei Chiao; Jerrold Fried; Monroe D. Dowling Jr.; Bayard D. Clarkson; Robert A. Good

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 352 KB
Volume: 39
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(197703)39:3<1101::aid-cncr2820390314>3.0.co;2-4

No coin nor oath required. For personal study only.

✦ Synopsis

Spontaneous rosette formation with sheep erythrocytes (SRBC) was studied in the peripheral blood and bone marrow lymphoid cells from a patient whose leukemic cells appeared to be T-lymphocytes. Simultaneous morphological examination of the peripheral blood white cells indicated that they consisted of 21% lymphoblasts; 26% prolymphocytes and 48% mature lymphocytes. The distribution of bone marrow cells within the cell cycle was determined by flow microfluorometry and 7 hours after treatment with vincristine consisted of 69% in G , , 21% in S, and 9% in mitosis. Since virtually all the cells both in marrow and blood formed rosettes with SRBC this implies that the expression of this T cell marker is independent both of the morphological appearance of these cells and their position within the cell cycle.

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