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Relationship between levels of Skp2 and P27 in breast carcinomas and possible role of Skp2 as targeted therapy

✍ Scribed by Wei-qiang Zheng; Jian-ming Zheng; Rong Ma; Feng-fang Meng; Chan-rong Ni

Book ID
116891838
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
281 KB
Volume
70
Category
Article
ISSN
0039-128X

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## BACKGROUND. Previous studies have shown that low levels of p27 Kip1 , an inhibitor of G1 cyclin-dependent kinases, are associated with high aggressiveness and poor prognosis in a variety of cancers. Decreased levels of p27 are caused, at least in part, by acceleration of the rate of its ubiquit