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Inverse relation between levels of p27Kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

✍ Scribed by Dan Hershko; Gil Bornstein; Ofer Ben-Izhak; Andrea Carrano; Michele Pagano; Michael M. Krausz; Avram Hershko

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
390 KB
Volume
91
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

Previous studies have shown that low levels of p27 Kip1 , an inhibitor of G1 cyclin-dependent kinases, are associated with high aggressiveness and poor prognosis in a variety of cancers. Decreased levels of p27 are caused, at least in part, by acceleration of the rate of its ubiquitin-mediated degradation. In cultured cells and cell-free biochemical systems, it has been shown that p27 is targeted for degradation by a ubiquitin ligase complex that contains Skp2 (S-phase kinaseassociated protein 2) as the specific substrate-recognizing and rate-limiting subunit. This investigation was undertaken to examine the possible relation between levels of p27 and of its specific ubiquitin ligase subunit Skp2 in human cancers.

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Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma : Relation to p27Kip1 and its Ubiquitin Ligase Subunit, S Phase Kinase Protein 2
✍ Ma'anit Shapira; Ofer Ben-Izhak; Bishara Bishara; Boris Futerman; Ira Minkov; Mi πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 250 KB πŸ‘ 2 views

## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio