## BACKGROUND. Previous studies have shown that low levels of p27 Kip1 , an inhibitor of G1 cyclin-dependent kinases, are associated with high aggressiveness and poor prognosis in a variety of cancers. Decreased levels of p27 are caused, at least in part, by acceleration of the rate of its ubiquit
The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma
✍ Scribed by Ma'anit Shapira; Ofer Ben–Izhak; Shai Linn; Boris Futerman; Ira Minkov; Dan D. Hershko
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 475 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The expression of Skp2, the ubiquitin ligase subunit that targets p27^Kip1^ for degradation, is commonly overexpressed in human cancers. p27^Kip1^ is a negative regulator of the cell cycle that plays an important role in tumor suppression. Loss of p27^Kip1^ secondary to enhanced ubiquit
## Abstract Previous work showed a genetic control of cell cycle deregulation during hepatocarcinogenesis. We now evaluated in preneoplastic lesions, dysplastic nodules and hepatocellular carcinoma (HCC), chemically induced in genetically susceptible F344 and resistant Brown Norway (BN) rats, the r
## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio
## Abstract ## BACKGROUND The stabilization of telomere lengths by telomerase activation is an important step in carcinogenesis and cell immortalization. Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of this enzyme. The objective of this study was to evaluate the use of r
Expression of the secretory component (SC) of IgA was investigated in normal colonic mucosa, in adenomas and in I88 colon carcinomas. Of the carcinoma patients, 149 underwent potentially curative surgical treatment. In particular, it was of interest to determine whether pathohistological or clinical