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Expression of p27 and its ubiquitin ligase subunit Skp2 in upper urinary tract transitional cell carcinoma

โœ Scribed by Cord Langner; Reinhard von Wasielewski; Manfred Ratschek; Peter Rehak; Richard Zigeuner

Book ID
116944360
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
295 KB
Volume
64
Category
Article
ISSN
0090-4295

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## BACKGROUND. Previous studies have shown that low levels of p27 Kip1 , an inhibitor of G1 cyclin-dependent kinases, are associated with high aggressiveness and poor prognosis in a variety of cancers. Decreased levels of p27 are caused, at least in part, by acceleration of the rate of its ubiquit