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Relationship between internalization and cytotoxicity of ricin A-chain immunotoxins

✍ Scribed by F. W. M. B. Preijers; W. J. M. Tax; T. De Witte; Anke Janssen; Hélènev.d. Heijden; H. Vidal; J. M. C. Wessels; P. J. A. Capel

Book ID
114711423
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
537 KB
Volume
70
Category
Article
ISSN
0007-1048

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lmmunotoxins were constructed by attaching native ricin A chain, ricin A, chain and recombinant r i c h A chain to the mouse monoclonal IgG,, antibody Fib75 by means of a disulphide linkage using the hetero-bifunctional cross-linker SPDP. The Fib75 immunotoxins were of similar composition and exerte