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Ricin B chain-containing immunotoxins prepared with heat-denatured B chain lacking galactose-binding ability potentiate the cytotoxicity of a cell-reactive ricin A chain immunotoxin

โœ Scribed by Edward J. Wawrzynczak; Alex F. Drake; Graham J. Watson; Philip E. Thorpe; Ellen S. Vitetta


Book ID
117046836
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
885 KB
Volume
971
Category
Article
ISSN
0005-2728

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Ricin A chain-containing immunotoxins (IT-As) specific for the human &ell antigen, CD22, were prepared from 4 monoclonal antibodies (MAbs) or their Fab' fragments: RFB4, HD6, UV22-I and UV22-2. The ITS were tested for their ability to kill cells from the Burkitt lymphoma line, Daudi, the pre-6cell l