Relationship between effect of activated charcoal on drug absorption in man and its drug adsorption characteristics in vitro
โ Scribed by Tamehiro Tsuchiya; Gerhard Levy
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 440 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3549
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The adsorption of diphenoxylate hydrochloride, a POtent antidiarrheal agent, on activated charcoal powder was studied in uitro. Langmuir adsorption isotherms were established a t pH 4 and 7, and the maximum adsorption capacity of charcoal for this drug was estimated using these values. Activated cha
The aim of the present work was to establish appropriate conditions for the dissolution/permeation system (D/P system) to estimate the effect of food intake on oral drug absorption. The D/P system is an in vitro assay system to evaluate the drug dissolution and permeation processes after oral admini