In vitro adsorption of diphenoxylate hydrochloride on activated charcoal and its relationship to pharmacological effects of drug in vivo I

✍ Scribed by Dilip R. Sanvordeker; Esam Z. Dajani

• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 347 KB
• Volume: 64
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600641129

✦ Synopsis

The adsorption of diphenoxylate hydrochloride, a POtent antidiarrheal agent, on activated charcoal powder was studied in uitro. Langmuir adsorption isotherms were established a t pH 4 and 7, and the maximum adsorption capacity of charcoal for this drug was estimated using these values. Activated charcoal modified the bioavailability of diphenoxylate hydrochloride in uiuo. The antipropulsive action of diphenoxylate in the mowe was strongly inhibited in the presence of activated charcoal. A comparative evaluation of charcoal and chromium oxide used as inert, nonabsorbable markers revealed that chromium oxide may be the marker of choice in GI transit studies in laboratory animals since it does not influence the bioavailability of diphenoxylate hydrochloride.