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Relationship between Development of Diarrhea and the Concentration of SN-38, an Active Metabolite of CPT-11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT-11

✍ Scribed by Araki, Eiji ;Ishikawa, Masayuki ;Iigo, Masaaki ;Koide, Tsutomu ;Itabashi, Masayuki ;Hoshi, Akio


Book ID
108579671
Publisher
Wiley (Blackwell Publishing)
Year
1993
Tongue
English
Weight
426 KB
Volume
84
Category
Article
ISSN
0910-5050

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High-performance liquid chromatographic
✍ Nobumitsu Hanioka; Hideto Jinno; Tetsuji Nishimura; Masanori Ando; Shogo Ozawa; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB 👁 1 views

## Abstract A simple and sensitive assay for glucuronidation activity of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), the active metabolite of irinotecan (CPT‐11), in human liver microsomes by high‐performance liquid chromatography (HPLC) with fluorescence detection is reported. The method was validated