Relationship between delta-aminolevulinic acid dehydratase genotypes and heme precursors in lead workers
β Scribed by Tadashi Sakai; Yoko Morita; Takaharu Araki; Mitsumasa Kano; Tsutomu Yoshida
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 121 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0271-3586
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Both blood lead and erythrocyte delta-aminolevulinic acid dehydratase (ALA-D) activity were determined for workers with and without an occupational lead exposure. In workers occupationally exposed to lead, it was demonstrated that the erythrocyte ALA-D is markedly activated by heating the hemolysate
The first intermediate substrate in the heme synthetic pathway, 5-aminolevulinic acid (ALA), is neurotoxic in animal models and may be responsible for some of the adverse neurologic outcomes in lead poisoning and porphyria in adult humans. ALA is a substrate for the enzyme aminolevulinic acid dehydr
The relationship between the activities of both pyrimidine 5'-nucleotidase (Py5N) and delta-aminolevulinate dehydratase (ALA-D) in erythrocytes and the concentration of lead in blood was investigated in the mice which were given ad libitum a drinking water containing lead of 10 to 500 ppm, for 30 da