The first intermediate substrate in the heme synthetic pathway, 5-aminolevulinic acid (ALA), is neurotoxic in animal models and may be responsible for some of the adverse neurologic outcomes in lead poisoning and porphyria in adult humans. ALA is a substrate for the enzyme aminolevulinic acid dehydr
Polymorphism of delta-aminolevulinic acid dehydratase in lead-exposed workers
β Scribed by B. Ziemsen; J. Angerer; G. Lehnert; H.-G. Benkmann; H. W. Goedde
- Publisher
- Springer-Verlag
- Year
- 1986
- Tongue
- English
- Weight
- 108 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0340-0131
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The measurement of 6-aminolevulinic acid dehydratase (ALA D) activity is a good index of lead exposure Recently, we proposed an immunotubidimetric assay which allows determination of the amount of the enzyme This last test is particularly interesting for workers presenting high blood-lead levels We
Both blood lead and erythrocyte delta-aminolevulinic acid dehydratase (ALA-D) activity were determined for workers with and without an occupational lead exposure. In workers occupationally exposed to lead, it was demonstrated that the erythrocyte ALA-D is markedly activated by heating the hemolysate