Relation of HLA class I and II supertypes with spontaneous clearance of hepatitis C virus
โ Scribed by Kuniholm, M H; Anastos, K; Kovacs, A; Gao, X; Marti, D; Sette, A; Greenblatt, R M; Peters, M; Cohen, M H; Minkoff, H; Gange, S J; Thio, C L; Young, M A; Xue, X; Carrington, M; Strickler, H D
- Book ID
- 120595940
- Publisher
- Nature Publishing Group
- Year
- 2013
- Tongue
- English
- Weight
- 261 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1466-4879
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Clearance of acute hepatitis B virus (HBV) infection is associated with a vigorous CD4+ T-cell response focusing on the core protein. HLA class II glycoproteins present viral peptides to CD4+ T cells and influence the immune responses. HLA-DRB1\*1301/2 have been associated with viral clearance, and
Spontaneous resolution of chronic hepatitis C virus (HCV) infection is exceedingly rare and poorly understood. As HCV and human immunodeficiency virus (HIV) have shared routes of transmission, HCV coinfection is estimated to affect 15%-30% of the HIV-positive population. We report 2 patients with HC