✦ LIBER ✦

Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus

✍ Scribed by Vishal Bhagat; Julie A. Foont; Eugene R. Schiff; Arie Regev

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 95 KB
Volume: 14
Category: Article
ISSN: 1527-6465
DOI: 10.1002/lt.21351

No coin nor oath required. For personal study only.

✦ Synopsis

Spontaneous resolution of chronic hepatitis C virus (HCV) infection is exceedingly rare and poorly understood. As HCV and human immunodeficiency virus (HIV) have shared routes of transmission, HCV coinfection is estimated to affect 15%-30% of the HIV-positive population. We report 2 patients with HCV-HIV coinfection who underwent orthotopic liver transplantation at our center and had spontaneous clearance of their chronic HCV infection after transplantation without any anti-HCV treatment. Both patients showed no evidence of HCV recurrence for more than 3 years despite long-term immunosuppressant therapy. Spontaneous clearance of chronic HCV infection can occur in HIV-HCV-coinfected patients after liver transplantation. The mechanism of this phenomenon remains unclear.

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