Association between HLA class II genotype and spontaneous clearance of hepatitis C viraemia
โ Scribed by Matthew E. Cramp; Patrizia Carucci; James Underhill; Nikolai V. Naoumov; Roger Williams; Peter T. Donaldson
- Book ID
- 118567836
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 120 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0168-8278
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Clearance of acute hepatitis B virus (HBV) infection is associated with a vigorous CD4+ T-cell response focusing on the core protein. HLA class II glycoproteins present viral peptides to CD4+ T cells and influence the immune responses. HLA-DRB1\*1301/2 have been associated with viral clearance, and
## Abstract Treating acute hepatitis C with interferon alpha prevents chronicity in nearly all cases when therapy is initiated within 3 months after infection. However, 15โ50% of untreated patients may clear the hepatitis C virus (HCV) spontaneously. Therefore, factors are needed to identify patien
autoantibodies (anti-nuclear [ANA], 10 anti-smooth muscle To investigate the factors that may confer susceptibil- [SMA], 11 anti-GOR, 12 anti-liver, kidney microsomes [LKM] ity or protection to hepatitis C virus (HCV) infection and antibodies 13 ). Despite these observations, however, it reto HCV-a