𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Rejection of tumor cells in vitro: A T-cell-mediated reaction

✍ Scribed by I. Berczi; A. H. Sehon

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
699 KB
Volume
16
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Cytotoxic lymphoblasts (LBC) were produced by the co‐cultivation of guinea‐pig lymphoid cells from the thymus, lymph nodes, spleen, bone marrow and blood with syngeneic methylcholanthrene‐induced sarcoma (MC‐D) cells. The cytotoxic reaction was inhibited by pretreatment of the lymphoid cell populations with a rabbit antiserum specific for guinea‐pig thymus‐derived (T) lymphocytes. Supernatants of LBC inhibited the migration of peritoneal exudate cells, but did not contain lymphotoxin or a skin reactive factor. It is concluded that the cytotoxic cells are of T‐cell origin.

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