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Telomerase-specific T-cells kill pancreatic tumor cells in vitro and in vivo

✍ Scribed by Jan Schmidt; Eduard Ryschich; Elisabeth Sievers; Ingo G. H. Schmidt-Wolf; Markus W. Büchler; Angela Märten

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 159 KB
Volume: 106
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.21655

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## Abstract Valproic acid (VA) is a well‐tolerated drug used to treat seizure disorders and has recently been shown to inhibit histone deacetylase (HDAC). Because HDAC modulates chromatin structure and gene expression, parameters considered to influence radioresponse, we investigated the effects of