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Cell interactions in adoptive immune rejection of a syngeneic tumor

✍ Scribed by Stephen B. Howell; Jack H. Dean; Elaine C. Esber; Lloyd W. Law

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
897 KB
Volume
14
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Studies of adoptive tumor neutralization (the Winn test) in BALB/c mice rendered immune to the Simian Virus 40‐induced tumor mKSA indicate that: a) the reaction is extremely specific; b) there is a very close correlation between immunity detected by the Winn test and the ability of the intact animal to reject tumor; and c) immunity reflected by the ^51^chromium lymphocytotoxicity assay (CRA) and microcytotoxicity test (MCI) correlate poorly with in vivo resistance to tumor challenge and the Winn test. Investigation of the contribution of the immune donor lymphocytes to the reaction demonstrated that immune thymus‐dependent lymphocytes (T cells) were essential, but other donor cell populations were not. Proliferation of immune donor cells was not required. Recipient T cells do not participate in the reaction. We propose that donor T cells do not attack the tumor directly, but must interact with recipient cells to generate an effector response. Some of the parameters of the postulated cooperative interaction are discussed.

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