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Reinvestigation of alternative method for the preparation of dibenz[b,f][1,4]oxazepine

✍ Scribed by Hossein Fakhraian; Yaser Nafary

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
86 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Two distinct alternative methods using different starting materials for the preparation of dibenz[b,f][1, 4]oxazepine (7, CR) were reinvestigated. The possibility of trans‐cis conversion of the Schiff base 5cis, 5trans (produced from 1 and 2) is considered the favorable orientation that leads to cyclization (production of 7). Fluoro derivative of 1 afforded excellent and more convenient conditions for the one pot preparation of high yield pure 7. The presence of only trans configuration for the imine 6cis, 6trans (produced from 3 with 4) and the impossibility of its conversion to cis, makes it inadequate for the preparation of 7. J. Heterocyclic Chem., (2009).

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Improved etherification procedure for th
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✍ H. Fakhraian; Y. Nafary; A. Yarahmadi; H. Hadj-Ghanbary πŸ“‚ Article πŸ“… 2008 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 200 KB

## Abstract magnified image The effect of temperature and catalyst on the yield and rate of the etherification reaction between **1** and **2** was investigated and alternative methods for separation of **3** and **4** from the reaction mixture have been described.

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The synthesis and chemistry of [11-14C]-
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## Abstract The synthesis of [11‐^14^C]‐dibenz[b,f][1,4]oxazepine 1 is described. Chromium trioxide – pyridine oxidation of 1 gives [11‐^14^C]‐10, 11‐dihydrodibenz [b,f][1,4] oxazepin‐11‐one 3 which on hydrolysis gives 2‐amino‐2′‐[^14^C]‐carboxydiphenylether 4. Hydrogenation of 1 affords [11‐^14^C]