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Regulation of β-globin gene expression: straightening out the locus

✍ Scribed by David IK Martin; Steven Fiering; Mark Groudine

Book ID
117655224
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
736 KB
Volume
6
Category
Article
ISSN
0959-437X

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## Abstract Many genes residing in gene clusters and expressed in a differentiation or developmental‐stage specific manner are regulated by locus control regions (LCRs). These complex genetic regulatory elements are often composed of several DNAse I hypersensitive sites (HS sites) that function tog