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Regulation of transferrin receptors by iron in human erythroblasts

โœ Scribed by Yasunobu Abe; Koichiro Muta; Junji Nishimura; Hajime Nawata


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
526 KB
Volume
40
Category
Article
ISSN
0361-8609

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## Abstract In human beings, serum transferrin levels increase during iron deficiency and decrease with iron overload. Yet, whether or not iron levels actually affect the synthesis of transferrin in human liver cells is not known. In previous studies, iron was shown to suppress the expression of ch

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## The hepatic uptake of transferrin-bound iron by a Iron is required for the synthesis of many heme and nontransferrin receptor (NTR)-mediated process was non-heme proteins and enzymes necessary for cellular investigated using the human hepatoma cell line HuH7. growth and metabolism. Most cells t