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Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation

✍ Scribed by Ji, Z; Degerny, C; Vintonenko, N; Deheuninck, J; Foveau, B; Leroy, C; Coll, J; Tulasne, D; Baert, J-L; Fafeur, V


Book ID
110070801
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
266 KB
Volume
26
Category
Article
ISSN
0950-9232

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Overexpression of the HER2/Neu receptor is correlated to a poor prognosis in tumor patients and leads to stimulation of mitogen-activated protein kinase (MAPK) signaling pathways, which in turn activate transcription factors, such as the ETS protein ER81. Here, we have analyzed whether, on the other