Regulation of αB-crystallin gene expression by the transcription factor Ets1 in breast cancer
✍ Scribed by Joshua D. Bosman; Fruma Yehiely; Joseph R. Evans; Vincent L. Cryns
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 414 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0167-6806
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## Abstract The Brn‐3b transcription factor has been shown to be overexpressed in human breast cancer cells and contributes toward cell growth regulation. Using micro‐arrays, more than 50 cancer‐related genes regulated by Brn‐3b in human breast cancer cells have been identified. For example, Brn‐3b
The PEA3 group of transcription factors belongs to the ets family and is composed of 3 known members, PEA3, ERM and ER81, which are more than 95% identical within the DNAbinding ETS domain and exhibit 50% aa identity overall. Recently, transgenic mice bearing the c-erbB-2/neu oncogene have been show