Regulation of inducible gene expression by the transcription factor NF-κB
✍ Scribed by Sankar Ghosh
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 743 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0257-277X
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The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-kappa B (NF-kappa B) transcription factors which are normally resident in the cytoplasm. Recent findings high
The redox state has been shown to regulate a variety of biochemical functions including cellular proliferation. Previous studies from our laboratory and others have shown that the binding of many transcription factors to their cognate DNA sequences is sensitive to the redox environment. Therefore, i