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The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

✍ Scribed by Steve Gerondakis; Raelene Grumont; Ian Rourke; Mathis Grossmann

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
636 KB
Volume
10
Category
Article
ISSN
0952-7915

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✦ Synopsis

The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-kappa B (NF-kappa B) transcription factors which are normally resident in the cytoplasm. Recent findings highlight the crucial roles of specific Rel/NF-kappa B family members in the processes of cell division, apoptosis and differentiation that accompany lymphocyte activation.

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