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Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis

✍ Scribed by Olof Rådmark; Bengt Samuelsson

Book ID
116300002
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
413 KB
Volume
396
Category
Article
ISSN
0006-291X

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✍ Thomas G. Brock 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 176 KB

## Abstract Leukotrienes are lipid messengers involved in autocrine and paracrine cellular signaling. They are synthesized from arachidonic acid by the 5‐lipoxygenase pathway. Current models of this enzymatic pathway recognize that a key step in initiating leukotriene synthesis is the calcium‐media