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Regulating leukotriene synthesis: The role of nuclear 5-lipoxygenase

✍ Scribed by Thomas G. Brock

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
176 KB
Volume
96
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Leukotrienes are lipid messengers involved in autocrine and paracrine cellular signaling. They are synthesized from arachidonic acid by the 5‐lipoxygenase pathway. Current models of this enzymatic pathway recognize that a key step in initiating leukotriene synthesis is the calcium‐mediated movement of enzymes, including 5‐lipoxygenase, to intracellular membranes. However, 5‐lipoxygenase can be imported into or exported from the nucleus before calcium activation. As a result, its subcellular localization will affect its ability to be activated by calcium, as well as the membrane to which it binds and its interaction with other enzymes. This commentary focuses on the role of 5‐lipoxygenase compartmentation in determining its regulation and, ultimately, leukotriene synthesis. J. Cell. Biochem. © 2005 Wiley‐Liss, Inc.

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