Proteins phosphorylated at tyrosine residues in the developing rat brain have been identified with a focus on the nerve growth cone and synaptic terminal. Endogenous protein phosphorylation in membranes from a subcellular growth cone fraction of fetal rat brain revealed prominent 55-60 kD phosphotyr
Regulation of Phosphorylation of tau by Protein Kinases in Rat Brain
โ Scribed by Amitabha Sengupta; Inge Grundke-Iqbal; Khalid Iqbal
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 266 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0364-3190
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Myelin basic protein, an 80-kilodalton (kDa) protein in rat oligodendrocytes, and an 80-kDa basic protein in neuroblastoma x neonatal Chinese hamster brain explant hybrids were phosphorylated extensively when the cells were treated with either phorbol esters (TPA) or diacylglycerols (e.g., oleyoyl-a
In Alzheimer's disease (AD), a family of proteins collectively named tau are displaced from their normal association with microtubules and are found in in a hyperphosphorylated state deposited into paired helical filaments (PHFs). PHFs are the hallmark cytoskeletal pathology of the disease, and the
Whether or not a ganglioside influences the protein phosphorylation in the rat brain membrane fraction was investigated. Phosphorylation of the 72 kDa protein was significantly affected by the addition of 80 nM GQlb in vitro, which is far below the reported concentration of gangliosides that affects