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Regulation of neuroblast proliferation by hormones and growth factors in chemically defined medium

✍ Scribed by Doris K. Wu; Thomas Maciag; J. de Vellis

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
607 KB
Volume
136
Category
Article
ISSN
0021-9541

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✦ Synopsis

Pure neuronal cultures prepared from 6-day-old embryonic chick brains incorporated [3H1-thymidine in serum-free medium up to the 4th day in culture. The addition of insulin any time within this culture period caused an increase in thymidine incorporation. This increase in [3Hl-thymidine was correlated with an increase in cell number and percentage of labeling index. Triiodothyronine and endothelial cell growth factor were also active in stimulating [3H]-thymidine incorporation into chick neuroblasts. The effect of these trophic agents is unique since a variety of known mitogens tested were negative.

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