𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Down regulation and recovery of the epidermal growth factor receptor in serum supplemented versus defined medium

✍ Scribed by Mark Kegel; Joseph T. Tupper

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
489 KB
Volume
113
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The down regulation of surface membrane receptors for(^125^I) epidermal growth factor (EGF) has been evaluated in normal and SV40‐transformed human fibroblasts (WI38) under conditions of serum‐supplemented versus defined growth media. Both normal and transformed WI38 cells down regulate and recover the EGF receptor and these processes do not differ significantly in serum‐supplemented versus defined media. These data are in contrast to a recent study that reported that the HeLa cell does not down regulate the EGF receptor in defined media, whereas it does in serum‐supplemented media.

📜 SIMILAR VOLUMES

Regulation of metastatic ovarian cell in
Regulation of metastatic ovarian cell in serum-free medium by epidermal growth factor and transferrin
✍ John T. Turner; James H. Wyche 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 550 KB

A rat ovarian tumorous cell line (OVlN) has been isolated and established in tissue culture whose growth can be controlled by the addition of epidermal growth factor (EGF) and transferrin to serum-free medium. EGF at 1 ng/ml (1.5 x 10-l0M) stimulates growth about 300% in a six-day incubation assay.

Epidermal growth factor expression in hu
Epidermal growth factor expression in human colon and colon carcinomas: Anti-sense epidermal growth factor receptor rna down-regulates the proliferation of human colon cancer cells
✍ Sriram Rajagopal; Shuang Huang; Thomas L. Moskal; Bang-Ning Lee; Adel K. El-Nagg 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 961 KB

## Abstract Human colon cancer cell lines express epidermal growth factor (EGF) mRNA, secrete EGF and may respond to it __via__ the cell‐surface EGF receptor (EGFR). Expression of these molecules in human colon and colon tumor, however, is not clear. Reverse transcription‐polymerase chain reaction

Detection of epidermal growth factor rec
Detection of epidermal growth factor receptor in the serum of gastric carcinoma patients
✍ Jin-Hyuk Choi; Jee Young Oh; Sung Ki Ryu; Seung Jung Kim; Na Young Lee; Young Su 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 79 KB 👁 2 views

malignancies including carcinoma of the breast, lung, esophagus, cervix, and stomach. In patients with gastric carcinoma, its overexpression may be associated with

Expression and regulation of the novel v
Expression and regulation of the novel vascular endothelial growth factor receptor neuropilin-1 by epidermal growth factor in human pancreatic carcinoma
✍ Alexander A. Parikh; Wen Biao Liu; Fan Fan; Oliver Stoeltzing; Niels Reinmuth; C 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 792 KB

## Abstract ## BACKGROUND It was recently shown that neuropilin‐1 (NRP‐1), which was described originally as a receptor for the semaphorins/collapsins (ligands involved in neuronal guidance), is a coreceptor for vascular endothelial growth factor (VEGF) and increases the affinity of specific isofo

Down-regulation of epidermal growth fact
Down-regulation of epidermal growth factor receptor-signaling pathway by binding of GRP78/BiP to the receptor under glucose-starved stress conditions
✍ Bing Cai; Akihiro Tomida; Koji Mikami; Kazuhiro Nagata; Takashi Tsuruo 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 166 KB

GRP78/BiP, a molecular chaperone in the endoplasmic reticulum, is induced under such adverse conditions for cell survival as glucose starvation. Induction of GRP78 has been shown to coincide with G1 cell cycle arrest, which is an important cellular defense system. In this study, we investigated invo

Down-regulation of epidermal growth fact
Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells
✍ Luisa Salvatori; Francesca Caporuscio; Giuseppe Coroniti; Giuseppe Starace; Luig 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 446 KB

## Abstract In previous studies on HeLa cells we demonstrated estrogen‐responsiveness of the epidermal growth factor receptor (EGFR) gene, as 17β‐estradiol (E~2~) and selective estrogen receptor modulators (SERMs) genistein (G), daidzein (D), and 4‐hydroxytamoxifen (4OH‐T) modulated its transcripti