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Regulation of mammalian LINE1 retrotransposon transcription

✍ Scribed by A. V. Fedorov


Book ID
111471505
Publisher
Pleiades Publishing
Year
2009
Tongue
English
Weight
570 KB
Volume
3
Category
Article
ISSN
1990-519X

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LINE-1 (L1) retrotransposons are replicating repetitive elements that, by mass, are the most-abundant sequences in the human genome. Over one-third of mammalian genomes are the result, directly or indirectly, of L1 retrotransposition. L1 encodes two proteins: ORF1, an RNA-binding protein, and ORF2,