Regulation of keratinocyte proliferation and differentiation by all-trans-retinoic acid, 9-cis-retinoic acid and 1,25-dihydroxy vitamin D3
β Scribed by S. Gibbs; C. Backendorf; M. Ponec
- Publisher
- Springer-Verlag
- Year
- 1996
- Tongue
- English
- Weight
- 598 KB
- Volume
- 288
- Category
- Article
- ISSN
- 0340-3696
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All-trans retinoic acid (ATRA) induces granulocytic maturation of WEHI-3B D+ leukemia cells and LiCl enhances this maturation, while WEHI-3B D- cells are non-responsive to ATRA. Transfection of SCL, expressed in D- but absent in D+ cells, into D+ cells, caused resistance to ATRA, while transfection
## Abstract 9__βcis__βRetinoic acid (9cRA) and 1Ξ±,25βdihydroxyvitamin D~3~ (1,25D) show promise as potential chemopreventive agents. We examined 9cRA and 1,25D, alone and in combination, for their potential to inhibit carcinogen (NNK)βinduced lung carcinogenesis in A/J mice. A/J mice (__n__ = 14/gr