Mechanisms of constitutive activation of
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Tai-Sung Lee; Wanlong Ma; Xi Zhang; Francis Giles; Hagop Kantarjian; Maher Albit
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Article
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2009
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John Wiley and Sons
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English
β 911 KB
## Abstract ## BACKGROUND: The tyrosine kinase Janus kinase 2 (JAK2) is important in triggering nuclear translocation and regulation of target genes expression through signal transducer and activator of transcription pathways. The valineβtoβphenylalanine mutation at amino acid 617 (V617F), which r