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Assessing the Extent of Membrane Penetration by the Pleckstrin Homology Domain of GRP1: Insights from Molecular Dynamics Simulations

โœ Scribed by Lumb, Craig N.; Stansfeld, Phillip J.; Sansom, Mark S.P.


Book ID
119208442
Publisher
Biophysical Society
Year
2011
Tongue
English
Weight
69 KB
Volume
100
Category
Article
ISSN
0006-3495

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## Abstract The SL1 stemโ€loop is the dimerization initiation site for linking the two copies of the RNA forming the HIVโ€1 genome. The 26 nucleotides stem contains a defect consisting on a highly conserved Gโ€rich 1โ€3 asymmetrical internal loop, which is a major site for nucleocapsid protein binding.