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Dimer Interface of Transmembrane Domains for neu/erbB-2 Receptor Dimerization and Transforming Activation: a Model Revealed by Molecular Dynamics Simulations

✍ Scribed by Sajot, Nicolas; Genest, Monique


Book ID
118227545
Publisher
Adenine Press
Year
2001
Tongue
English
Weight
205 KB
Volume
19
Category
Article
ISSN
0739-1102

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Molecular modeling of c-erbB2 receptor d
✍ Norbert Garnier; Daniel Genest; Jean Pierre Duneau; Monique Genest πŸ“‚ Article πŸ“… 1997 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 210 KB πŸ‘ 2 views

Dimerization models of c-erbB2 transmembrane domains (Leu651-Ile675) are studied by molecular mechanics and molecular dynamics simulations. Both wild and Glu mutated transmembrane helices exhibit the same relative orientation for favorable associations and dimerize preferentially in left-handed coil