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Dimer models for ErbB-2/neu transmembrane domains from molecular dynamics simulations

✍ Scribed by Nicolas Sajot; Norbert Garnier; Monique Genest


Publisher
Springer
Year
1999
Tongue
English
Weight
203 KB
Volume
101
Category
Article
ISSN
1432-2234

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Molecular modeling of c-erbB2 receptor d
✍ Norbert Garnier; Daniel Genest; Jean Pierre Duneau; Monique Genest 📂 Article 📅 1997 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 210 KB 👁 2 views

Dimerization models of c-erbB2 transmembrane domains (Leu651-Ile675) are studied by molecular mechanics and molecular dynamics simulations. Both wild and Glu mutated transmembrane helices exhibit the same relative orientation for favorable associations and dimerize preferentially in left-handed coil