Structure prediction of the dimeric neu/ErbB-2 transmembrane domain from multi-nanosecond molecular dynamics simulations
✍ Scribed by Nicolas Sajot; Monique Genest
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 516 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1432-1017
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Dimerization models of c-erbB2 transmembrane domains (Leu651-Ile675) are studied by molecular mechanics and molecular dynamics simulations. Both wild and Glu mutated transmembrane helices exhibit the same relative orientation for favorable associations and dimerize preferentially in left-handed coil