✦ LIBER ✦

Regulation of heat shock protein synthesis in rat astroeytes

✍ Scribed by Dr. B. E. Dwyer; R. N. Nishimura; J. De Vellis; K. B. Clegg

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 756 KB
Volume: 28
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490280306

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Rat forebrain astrocytes synthesize heat shock proteins with molecular weights 97,89,70,68, and 30‐34 kilodaltons. The stress inducible 68‐kDa heat shock protein (HSP‐68) was vigorously expressed by astro‐cytes in culture after a 45°C, 20 min heat shock. HSP‐68 synthesis was poorly inducible by a second heat shock given 16 hr after the initial heat shock. Decreased [^35^S]methionine incorporation into HSP‐68 correlated with low levels of HSP‐68 mRNA present after the second heat shock. The data suggest that control of HSP‐68 mRNA levels by transcriptional/ posttranscriptional mechanisms is a major site for regulation of HSP‐68 synthesis.

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