When cells are subjected to various stress factors, they increase the production of a group of proteins called heat shock proteins (hsp). Heat shock proteins are highly conserved proteins present in organisms ranging from bacteria to man. Heat shock proteins enable cells to survive adverse environme
Heat shock proteins and regulation of cytokine expression
โ Scribed by Y. Xie; C.M. Cahill; A. Asea; P.E. Auron; S.K. Calderwood
- Publisher
- Hindawi Publishing Corporation
- Year
- 1999
- Tongue
- English
- Weight
- 236 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1064-7449
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๐ SIMILAR VOLUMES
H eat shock proteins (hsps) are among the most abundant proteins in nature and are highly conserved amongst both eucaryotes and procaryotes. The heat shock response is an important survival mechanism that safeguards the cell or microbe from conditions of stress. The response is triggered transcripti
In normal muscle, 65-kd heat shock proteins (hsp) were detected on capillary endothelial cells, the mural elements of larger vessels, and some intracellular organelles, probably mitochondria. In the inflammatory myopathies, the 65-kd hsp were detected on inflanunaxory cells, degenerating and regener
Constitutive expression of human hsp27 resulted in a 100-fold increase in survival to a single lethal heat shock in CHO cells without effecting the development of thermotolerance. A possible mechanism for the thermoprotective function of hsp27 may be increased recovery of protein synthesis and RNA s