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Regulation of exoprotein gene expression in Staphylococcus aureus by agr

✍ Scribed by Recsei, P. ;Kreiswirth, B. ;O'Reilly, M. ;Schlievert, P. ;Gruss, A. ;Novick, R. P.

Publisher: Springer
Year: 1986
Tongue: English
Weight: 604 KB
Volume: 202
Category: Article
ISSN: 0026-8925
DOI: 10.1007/bf00330517

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✦ Synopsis

Insertion of the erythromycin-resistance transposon Tn551 into the Staphylococcus aureus chromosome at a site which maps between the purB and ilv loci has a pleiotrophic effect on the production of a number of extracellular proteins. Production of alpha, beta and delta hemolysin, toxic shock syndrome toxin (TSST-I) and staphylokinase was depressed about fifty-fold while protein A production was elevated twenty-fold. Hybridization analysis showed that the defect in expression of TSST-1 and alpha hemolysin was at the transcriptional level. Inability of the mutant strain to express either a cloned TSST-1 gene or the chromosomal gene indicates that the transposon has inactivated a trans-active positive control element. This element has been designated agr for accessory gene regulator.

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