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Regulation of CYP3A4 and CYP3A5 expression and modulation of “intracrine” metabolism of androgens in prostate cells by liganded vitamin D receptor

✍ Scribed by Maguire, Orla; Pollock, Catherine; Martin, Philip; Owen, Andrew; Smyth, Thomas; Doherty, Declan; Campbell, Moray J.; McClean, Stephen; Thompson, Paul


Book ID
119323402
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
915 KB
Volume
364
Category
Article
ISSN
0303-7207

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We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a