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Regulation of clustered gene expression by cofactor of BRCA1 (COBRA1) in breast cancer cells

✍ Scribed by Aiyar, S E; Blair, A L; Hopkinson, D A; Bekiranov, S; Li, R

Book ID
110072052
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
365 KB
Volume
26
Category
Article
ISSN
0950-9232

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## Abstract Cofactor of BRCA1 (COBRA1) is an integral component of the human negative elongation factor (NELF), a four‐subunit protein complex that inhibits transcription elongation. Previous in vivo work indicates that COBRA1 and the rest of the NELF complex repress estrogen‐dependent transcriptio