BRCA1 gene expression in relation to prognostic parameters of breast cancer
β Scribed by Manal Kamal; Yasser H. Shaaban; Mohamed Shehata; Amr T. El-Kashif; Emmad E. Habib; Khadiga Abu Gabal; Samia El-Naggar
- Book ID
- 107616047
- Publisher
- PAGEPress Publications
- Year
- 2011
- Tongue
- English
- Weight
- 272 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1970-5557
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## Abstract Cofactor of BRCA1 (COBRA1) is an integral component of the human negative elongation factor (NELF), a fourβsubunit protein complex that inhibits transcription elongation. Previous in vivo work indicates that COBRA1 and the rest of the NELF complex repress estrogenβdependent transcriptio
BRCA1 is considered to be a tumor-suppressor gene, yet mutations in this gene are uncommon in sporadic breast tumors. We investigated whether mechanisms other than DNA mutations that affect the coding region might be involved in breast carcinogenesis. Since loss of expression of the BRCA1 gene would