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BRCA1 gene expression in relation to prognostic parameters of breast cancer

✍ Scribed by Manal Kamal; Yasser H. Shaaban; Mohamed Shehata; Amr T. El-Kashif; Emmad E. Habib; Khadiga Abu Gabal; Samia El-Naggar


Book ID
107616047
Publisher
PAGEPress Publications
Year
2011
Tongue
English
Weight
272 KB
Volume
5
Category
Article
ISSN
1970-5557

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BRCA1 is considered to be a tumor-suppressor gene, yet mutations in this gene are uncommon in sporadic breast tumors. We investigated whether mechanisms other than DNA mutations that affect the coding region might be involved in breast carcinogenesis. Since loss of expression of the BRCA1 gene would