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Regulation of cell proliferation and cell death by peroxisome proliferators

✍ Scribed by Russell C. Cattley

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
79 KB
Volume
61
Category
Article
ISSN
1059-910X

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✦ Synopsis

Abstract

Peroxisome proliferators cause increases in liver mass in rodents, linked to changes in cell proliferation and cell death of hepatocytes. These effects are reversible upon cessation of treatment. The underlying mechanism of the response in rodent liver is complex, but clearly dependent on activation of the nuclear receptor PPARα. Other signaling pathways have been implicated in this response, but evidence is mixed. Differing sensitivity among various species to effects of peroxisome proliferators has been associated with differences in PPARα expression and function. Changes in cell proliferation and cell death in neoplastic hepatocytes also have been found in liver tumors caused by long‐term treatment with peroxisome proliferators. Microsc. Res. Tech. 61:179–184, 2003. © 2003 Wiley‐Liss, Inc.

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