Platelet-derived growth factor (PDGF) is the most potent mitogen for hepatic stellate cells (HSCs) in vitro. The aim of this study was to investigate the role of the lipid-derived second messenger phosphatidic acid (PA) in mediating this effect and, in particular, to determine its interaction with t
Peroxisome proliferator-activated receptor γ transcriptional regulation is involved in platelet-derived growth factor–induced proliferation of human hepatic stellate cells
✍ Scribed by Andrea Galli; David Crabb; Donna Price; Elisabetta Ceni; Renata Salzano; Calogero Surrenti; Alessandro Casini
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 405 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
Abbreviations: HSC, hepatic stellate cells; ␣-SMA, ␣ smooth muscle actin; PDGF, platelet-derived growth factor; PPAR␥, peroxisome proliferator-activated receptor ␥; 9-cisRA, 9-cis retinoic acid; RXR, retinoic X receptor; 15d-PGJ 2 , 15-deoxy-⌬ 12,14 prostaglandin J 2 ; [ 3 H]TdR, [methyl-3 H]thymidine; PPRE, peroxisome proliferator response element; mRNA, messenger RNA; MAP, mitogen-activated protein.
📜 SIMILAR VOLUMES
Upon liver injury, hepatic stellate cells (HSC) show increased proliferation, motility, and extracellular matrix (ECM) production. The extracellular signal-regulated kinases (ERK) control different functions in a cell-specific manner. In this study, we evaluated the role of ERK activation in culture