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Regulation of Bcl-2 gene expression by BCR-ABL is mediated by Ras

✍ Scribed by Isidro Sánchez-Garcı́a; Dionisio Martı́n-Zanca

Book ID
115627723
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
227 KB
Volume
267
Category
Article
ISSN
0022-2836

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## Abstract Expression of BCR/ABL, a constitutively active tyrosine kinase, is a primary event in the pathogenesis of chronic myeloid leukemia (CML) and Ph‐positive acute lymphoblastic leukemia (Ph+ALL). Inhibition of the BCR/ABL kinase activity in the BV173 CML cell line with STI571 resulted in a