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Transcriptional suppression of BACH2 by the Bcr-Abl oncoprotein is mediated by PAX5

✍ Scribed by Casolari, D A; Makri, M; Yoshida, C; Muto, A; Igarashi, K; Melo, J V


Book ID
120430137
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
734 KB
Volume
27
Category
Article
ISSN
0887-6924

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Transcription factor BACH2 is transcript
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## Abstract Expression of BCR/ABL, a constitutively active tyrosine kinase, is a primary event in the pathogenesis of chronic myeloid leukemia (CML) and Ph‐positive acute lymphoblastic leukemia (Ph+ALL). Inhibition of the BCR/ABL kinase activity in the BV173 CML cell line with STI571 resulted in a