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Regulation of 3,3′,4,4′-Tetrachlorobiphenyl Induced Cytochrome P450 Metabolism by Thiols in Tissues of Rainbow Trout*

✍ Scribed by Diana M.E. Otto; Chandan K. Sen; William L. Casley; Thomas W. Moon

Book ID: 117567373
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 602 KB
Volume: 117
Category: Article
ISSN: 0742-8413
DOI: 10.1016/s0742-8413(97)00003-0

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## Abstract The effects of a single injection (40 mg/kg) of 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3) on hepatic cytochrome P‐450 monooxygenases were assessed in rat and syrian hamster. The CF3 treatment significantly increased the total amount of cytochrome P‐450 in both species. In rat