## Abstract The effects of a single injection (40 mg/kg) of 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3) on hepatic cytochrome P‐450 monooxygenases were assessed in rat and syrian hamster. The CF3 treatment significantly increased the total amount of cytochrome P‐450 in both species. In rat
✦ LIBER ✦
Interaction of 3,4,3′,4′-tetrachlorobiphenyl metabolites formed by cytochrome P-450 in vitro with rat erythrocytes
✍ Scribed by Tsutomu Shimada; Yoshiyuki Sawabe; Yumiko Nakano
- Publisher
- Springer-Verlag
- Year
- 1985
- Tongue
- English
- Weight
- 874 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0340-5761
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## Abstract Quinone toxicity is induced by two principal mechanisms: arylation/alkylation and a redox cycle. We have previously shown that increases in intracellular levels of superoxide anion and cell death induced by 2,3‐dimethoxy‐1,4‐naphthoquinone (DMNQ), a redox cycling quinone, are enhanced b